Excessive Sleepiness in Preclinical Alzheimer's Disease: The goal of this project is to clarify how specific, objective measures of sleepiness are associated with Alzheimer's Disease (AD) related biomarkers, in its preclinical form. Completing this project would advance the understanding of the relationship between sleepiness phenotypes and AD pathophysiology, which may lead to the development of improved screening and preventative therapeutic strategies for the disease.
Recruitment Status: Participants from the Wisconsin Alzheimer's Disease Research Center studies
The Symptom Science of Excessive Daytime Sleepiness - A Multidimensional Approach: The goal of this project is to advance the neurobiological understanding of sleepiness phenotypes. Specifically, the project aims to determine objective measures of sleepiness that associate with with local reductions in slow wave activity during sleep in the supramarginal gyrus/somatosensory cortex as well as reduced thalamostriatal functional
connectivity during wake.
Recruitment Status: Open
Previously Conducted Research:
Neurophysiologic Correlates of Hypersomnia: The goal of this project is to examine the neurophysiology of hypersomnia during sleep and wakefulness using high-density EEG, to identify biomarkers for excessive sleepiness in neuropsychiatric disorders, and pilot acoustical slow wave induction in patients with hypersomnolence as a novel treatment of hypersomnia.
Recruitment Status: Closed
ClinicalTrials.gov Identifier: NCT01719315
Utility of Multidimensional Approach for the Assessment of Hypersomnolence: The overall purpose of this study is to employ a pragmatic, multidimensional assessment of hypersomnolence that “piggybacks” on routine clinical care in patients with suspected disorders of central nervous system (CNS) hypersomnolence, to determine whether these additional objective and subjective assessments provide added benefit in the diagnosis and assessment of these disorders. Participants are recruited in conjunction with their clinical care provided at Wisconsin Sleep Center.
Recruitment Status: N/A (Clinical Patients)
ClinicalTrials.gov Identifier: NCT02884505